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Article

Involvement of the p53 and p73 transcription factors in neuroAIDS

1 Sept 2008

Abstract excerpt

HIV-associated dementia (HAD) is the most common AIDS-associated neurological disorder and is characterized by the development of synaptodendritic injury to neurons. To advance HAD therapy, it is crucial to identify the mechanisms and factors involved. The viral protein HIV-1 Tat is among those factors and is released by HIV-1-infected cells and can be taken up by adjacent neuronal cells leading to neurotoxic...

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PMID: 18719392
DOI: 10.4161/cc.7.17.6450

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