Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence for Activation of Endogenous Transporters in Xenopus laevis Oocytes Expressing the Plasmodium falciparum Chloroquine Resistance Transporter, PfCRT

17 Jul 2004

Abstract excerpt

A large body of genetic, reverse genetic, and epidemiological data has linked chloroquine-resistant malaria to polymorphisms within a gene termed pfcrt in the human malarial parasite Plasmodium falciparum. To investigate the biological function of the chloroquine resistance transporter, PfCRT, as well as its role in chloroquine resistance, we functionally expressed this protein in Xenopus laevis oocytes. Our data...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drug-Induced Hepatotoxicity and Protection
Share to Drug Transport and Resistance Mechanisms
Share to Malaria Research and Control

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15258157
DOI: 10.1074/jbc.m404671200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for Activation of Endogenous Transporters in Xenopus laevis Oocytes Expressing the Plasmodium falciparum Chloroquine Resistance Transporter, PfCRTPMID 15258157Read ↗

Iron is a substrate of the Plasmodium falciparum chloroquine resistance transporter PfCRT in Xenopus oocytes.Semantic proximity Read ↗

The Knock-Down of the Chloroquine Resistance Transporter PfCRT Is Linked to Oligopeptide Handling in Plasmodium falciparumSemantic proximity Read ↗

Chloroquine transport via the malaria parasite's chloroquine resistance transporter.Semantic proximity Read ↗

Functional characteristics of the malaria parasite's "chloroquine resistance transporter": implications for chemotherapy.Semantic proximity Read ↗

Chloroquine resistance modulated in vitro by expression levels of the Plasmodium falciparum chloroquine resistance transporter.Semantic proximity Read ↗

pfcrt is more than the Plasmodium falciparum chloroquine resistance gene: a functional and evolutionary perspective.Semantic proximity Read ↗

PfCRT-mediated drug transport in malarial parasites.Semantic proximity Read ↗

Chloroquine resistance-conferring mutations in pfcrt give rise to a chloroquine-associated H+ leak from the malaria parasite's digestive vacuole.Semantic proximity Read ↗

Differential stimulation of the Na+/H+ exchanger determines chloroquine uptake in Plasmodium falciparum.Semantic proximity Read ↗

On the mechanism of chloroquine resistance in Plasmodium falciparum.Semantic proximity Read ↗

Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter.Semantic proximity Read ↗

The antimalarial drug resistance protein Plasmodium falciparum chloroquine resistance transporter binds chloroquine.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.