Article
Chloroquine transport via the malaria parasite's chloroquine resistance transporter.
Science (New York, N.Y.) - 25 Sept 2009
Martin Rowena E, Marchetti Rosa V, Cowan Anna I, Howitt Susan M, Bröer Stefan, Kirk Kiaran
Abstract excerpt
The emergence and spread of chloroquine-resistant Plasmodium falciparum malaria parasites has been a disaster for world health. Resistance is conferred by mutations in the Chloroquine Resistance Transporter (PfCRT), an integral membrane protein localized to the parasite's internal digestive vacuole. These mutations result in a marked reduction in the accumulation of chloroquine (CQ) by the parasite. However, the...
Topics
- Amino Acid Sequence
- Animals
- Antimalarials
- Biological Transport
- Cell Membrane
- Chloroquine
- Drug Resistance
- Hydrogen-Ion Concentration
- Membrane Potentials
- Membrane Transport Proteins
- Molecular Sequence Data
- Mutant Proteins
- Mutation
- Oligopeptides