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Article

Iron is a substrate of the Plasmodium falciparum chloroquine resistance transporter PfCRT in Xenopus oocytes.

The Journal of biological chemistry - 29 Sept 2017

Bakouh Naziha, Bellanca Sebastiano, Nyboer Britta, Moliner Cubel Sonia, Karim Zoubida, Sanchez Cecilia P, Stein Wilfred D, Planelles Gabrielle, Lanzer Michael

Abstract excerpt

The chloroquine resistance transporter of the human malaria parasite Plasmodium falciparum, PfCRT, is an important determinant of resistance to several quinoline and quinoline-like antimalarial drugs. PfCRT also plays an essential role in the physiology of the parasite during development inside erythrocytes. However, the function of this transporter besides its role in drug resistance is still unclear. Using...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28768767
DOI: 10.1074/jbc.M117.805200
PMCID: PMC5625042

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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