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Article

Differential stimulation of the Na+/H+ exchanger determines chloroquine uptake in Plasmodium falciparum.

The Journal of cell biology - 26 Jan 1998

Wünsch S, Sanchez C P, Gekle M, Grosse-Wortmann L, Wiesner J, Lanzer M

Abstract excerpt

Here we describe the identification and characterization of a physiological marker that is associated with the chloroquine-resistant (CQR) phenotype in the human malarial parasite Plasmodium falciparum. Single cell in vivo pH measurements revealed that CQR parasites consistently have an elevated cytoplasmic pH compared to that of chloroquine-sensitive (CQS) parasites because of a constitutively activated Na+/H+...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 9442109
DOI: 10.1083/jcb.140.2.335
PMCID: PMC2132566

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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