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Article

Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect.

Genes & development - 1 Aug 2004

Oikemus Sarah R, McGinnis Nadine, Queiroz-Machado Joana, Tukachinsky Hanna, Takada Saeko, Sunkel Claudio E, Brodsky Michael H

Abstract excerpt

Terminal deletions of Drosophila chromosomes can be stably protected from end-to-end fusion despite the absence of all telomere-associated sequences. The sequence-independent protection of these telomeres suggests that recognition of chromosome ends might contribute to the epigenetic protection of telomeres. In mammals, Ataxia Telangiectasia Mutated (ATM) is activated by DNA damage and acts through an unknown,...

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Source

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Identifiers

PMID: 15256487
DOI: 10.1101/gad.1202504
PMCID: PMC517405

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Drosophila atm/telomere fusion is required for telomeric localization of HP1 and telomere position effect.PMID 15256487Read ↗

Epigenetic telomere protection by Drosophila DNA damage response pathways.Semantic proximity Read ↗

<i>Drosophila</i> ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenanceSemantic proximity Read ↗

tef: a mutation that causes telomere fusion and severe genome rearrangements in Drosophila melanogaster.Semantic proximity Read ↗

The terminal telomeric DNA sequence determines the mechanism of dysfunctional telomere fusion.Semantic proximity Read ↗

Molecular genetic characterization of Drosophila ATM conserved functional domains.Semantic proximity Read ↗

The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage.Semantic proximity Read ↗

ATM is required for telomere maintenance and chromosome stability during Drosophila development.Semantic proximity Read ↗

Effete, a Drosophila chromatin-associated ubiquitin-conjugating enzyme that affects telomeric and heterochromatic position effect variegation.Semantic proximity Read ↗

A product of the bicistronic Drosophila melanogaster gene CG31241, which also encodes a trimethylguanosine synthase, plays a role in telomere protection.Semantic proximity Read ↗

Organization and Evolution of Drosophila Terminin: Similarities and Differences between Drosophila and Human TelomeresSemantic proximity Read ↗

The Drosophila modigliani (moi) gene encodes a HOAP-interacting protein required for telomere protection.Semantic proximity Read ↗

HipHop interacts with HOAP and HP1 to protect Drosophila telomeres in a sequence-independent manner.Semantic proximity Read ↗

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