Article
Effete, a Drosophila chromatin-associated ubiquitin-conjugating enzyme that affects telomeric and heterochromatic position effect variegation.
Genetics - 1 Sept 2013
Cipressa Francesca, Romano Sabrina, Centonze Silvia, zur Lage Petra I, Vernì Fiammetta, Dimitri Patrizio, Gatti Maurizio, Cenci Giovanni
Abstract excerpt
Drosophila telomeres are elongated by the transposition of telomere-specific retrotransposons rather than telomerase activity. Proximal to the terminal transposon array, Drosophila chromosomes contain several kilobases of a complex satellite DNA termed telomere-associated sequences (TASs). Reporter genes inserted into or next to the TAS are silenced through a mechanism called telomere position effect (TPE). TPE...
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