Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage.

Current biology : CB - 10 Aug 2004

Ciapponi Laura, Cenci Giovanni, Ducau Judith, Flores Carlos, Johnson-Schlitz Dena, Gorski Marcin M, Engels William R, Gatti Maurizio

Abstract excerpt

The MRN complex consists of the two evolutionarily conserved components Mre11 and Rad50 and the third less-conserved component Nbs1/Xrs2. This complex mediates telomere maintenance in addition to a variety of functions in response to DNA double-strand breaks, including homologous recombination, nonhomologous end joining (NHEJ), and activation of DNA damage checkpoints. Mutations in the Mre11 gene cause the human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomal Proteins, Non-Histone
Share to Chromosome Breakage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Repair Enzymes

Share to Endodeoxyribonucleases

Share to Exodeoxyribonucleases

Share to Immunoblotting

Share to Indoles

Share to Telomere

Source

Identifiers

PMID: 15296753
DOI: 10.1016/j.cub.2004.07.019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Drosophila Mre11/Rad50 complex is required to prevent both telomeric fusion and chromosome breakage.PMID 15296753Read ↗

The MRN complex in double-strand break repair and telomere maintenance.Semantic proximity Read ↗

The Drosophila Nbs protein functions in multiple pathways for the maintenance of genome stability.Semantic proximity Read ↗

Mre11-Rad50-Nbs complex is required to cap telomeres during Drosophila embryogenesis.Semantic proximity Read ↗

The Mre11 complex and the metabolism of chromosome breaks: the importance of communicating and holding things together.Semantic proximity Read ↗

Multiple roles for MRE11 at uncapped telomeres.Semantic proximity Read ↗

Mre11–Rad50–Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin templateThis paper is one of a selection of papers published in this Special Issue, entitled 28th International West Coast Chromatin and Chromosome Conference, and has undergone the Journal's usual peer review process.Semantic proximity Read ↗

Mre11-Rad50-dependent activity of ATM/Tel1 at DNA breaks and telomeres in the absence of Nbs1.Semantic proximity Read ↗

Mre11 assembles linear DNA fragments into DNA damage signaling complexes.Semantic proximity Read ↗

Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.Semantic proximity Read ↗

Importance of Germline and Somatic Alterations in Human MRE11, RAD50, and NBN Genes Coding for MRN ComplexSemantic proximity Read ↗

A Survey of Reported Disease-Related Mutations in the MRE11-RAD50-NBS1 Complex.Semantic proximity Read ↗

The Rad50 hook domain regulates DNA damage signaling and tumorigenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.