Article
ATM is required for telomere maintenance and chromosome stability during Drosophila development.
Current biology : CB - 10 Aug 2004
Silva Elizabeth, Tiong Stanley, Pedersen Michael, Homola Ellen, Royou Anne, Fasulo Barbara, Siriaco Giorgia, Campbell Shelagh D
Abstract excerpt
ATM is a large, multifunctional protein kinase that regulates responses required for surviving DNA damage: including DNA repair, apoptosis, and cell cycle checkpoints. Here, we show that Drosophila ATM function is essential for normal adult development. Extensive, inappropriate apoptosis occurs in proliferating atm mutant tissues, and in clonally derived atm mutant embryos, frequent mitotic defects were seen. At...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.