<i>Drosophila</i> ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance

doi:10.1073/pnas.0504981102

Article

<i>Drosophila</i> ATM and ATR checkpoint kinases control partially redundant pathways for telomere maintenance

3 Oct 2005

Abstract excerpt

In higher eukaryotes, the ataxia telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) checkpoint kinases play distinct, but partially overlapping, roles in DNA damage response. Yet their interrelated function has not been defined for telomere maintenance. We discover in Drosophila that the two proteins control partially redundant pathways for telomere protection: the loss of ATM leads to the fusion of some...

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