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Article

HipHop interacts with HOAP and HP1 to protect Drosophila telomeres in a sequence-independent manner.

The EMBO journal - 17 Feb 2010

Gao Guanjun, Walser Jean-Claude, Beaucher Michelle L, Morciano Patrizia, Wesolowska Natalia, Chen Jie, Rong Yikang S

Abstract excerpt

Telomeres prevent chromosome ends from being repaired as double-strand breaks (DSBs). Telomere identity in Drosophila is determined epigenetically with no sequence either necessary or sufficient. To better understand this sequence-independent capping mechanism, we isolated proteins that interact with the HP1/ORC-associated protein (HOAP) capping protein, and identified HipHop as a subunit of the complex. Loss of...

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Identifiers

PMID: 20057353
DOI: 10.1038/emboj.2009.394
PMCID: PMC2829166

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HipHop interacts with HOAP and HP1 to protect Drosophila telomeres in a sequence-independent manner.PMID 20057353Read ↗

HP1 is distributed within distinct chromatin domains at Drosophila telomeres.Semantic proximity Read ↗

Umbrea, a chromo shadow domain protein in Drosophila melanogaster heterochromatin, interacts with Hip, HP1 and HOAP.Semantic proximity Read ↗

Taming active transposons at Drosophila telomeres: The interconnection between HipHop's roles in capping and transcriptional silencing.Semantic proximity Read ↗

Drosophila heterochromatin protein 1 (HP1)/origin recognition complex (ORC) protein is associated with HP1 and ORC and functions in heterochromatin-induced silencing.Semantic proximity Read ↗

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Paternal imprint essential for the inheritance of telomere identity in <i>Drosophila</i>Semantic proximity Read ↗

Heterochromatin protein 1 is recruited to various types of DNA damage.Semantic proximity Read ↗

Organization and Evolution of Drosophila Terminin: Similarities and Differences between Drosophila and Human TelomeresSemantic proximity Read ↗

Mutations in the heterochromatin protein 1 (HP1) hinge domain affect HP1 protein interactions and chromosomal distribution.Semantic proximity Read ↗

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Human POT1 Prevents Severe Telomere Instability Induced by Homology Directed DNA RepairSemantic proximity Read ↗

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