Article
The Drosophila modigliani (moi) gene encodes a HOAP-interacting protein required for telomere protection.
Proceedings of the National Academy of Sciences of the United States of America - 17 Feb 2009
Raffa Grazia D, Siriaco Giorgia, Cugusi Simona, Ciapponi Laura, Cenci Giovanni, Wojcik Edward, Gatti Maurizio
Abstract excerpt
Several proteins have been identified that protect Drosophila telomeres from fusion events. They include UbcD1, HP1, HOAP, the components of the Mre11-Rad50-Nbs (MRN) complex, the ATM kinase, and the putative transcription factor Woc. Of these proteins, only HOAP has been shown to localize specifically at telomeres. Here we show that the modigliani gene encodes a protein (Moi) that is enriched only at telomeres,...
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