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Article

Functional complementation of human centromere protein A (CENP-A) by Cse4p from Saccharomyces cerevisiae.

Molecular and cellular biology - 1 Aug 2004

Wieland Gerhard, Orthaus Sandra, Ohndorf Sabine, Diekmann Stephan, Hemmerich Peter

Abstract excerpt

We have employed a novel in vivo approach to study the structure and function of the eukaryotic kinetochore multiprotein complex. RNA interference (RNAi) was used to block the synthesis of centromere protein A (CENP-A) and Clip-170 in human cells. By coexpression, homologous kinetochore proteins from Saccharomyces cerevisiae were then tested for the ability to complement the RNAi-induced phenotypes. Cse4p, the...

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Identifiers

PMID: 15254229
DOI: 10.1128/MCB.24.15.6620-6630.2004
PMCID: PMC444843

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Source receipt: pubmed, retrieved 7 Sept 2026.

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