Article
HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells.
PLoS biology - 1 Jul 2004
Oswald-Richter Kyra, Grill Stacy M, Shariat Nikki, Leelawong Mindy, Sundrud Mark S, Haas David W, Unutmaz Derya
Abstract excerpt
A T-cell subset, defined as CD4(+)CD25(hi) (regulatory T-cells [Treg cells]), was recently shown to suppress T-cell activation. We demonstrate that human Treg cells isolated from healthy donors express the HIV-coreceptor CCR5 and are highly susceptible to HIV infection and replication. Because Treg cells are present in very few numbers and are difficult to expand in vitro, we genetically modified conventional...
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