Article
Gene editing to induce FOXP3 expression in human CD4+ T cells leads to a stable regulatory phenotype and function.
Science translational medicine - 3 Jun 2020
Honaker Yuchi, Hubbard Nicholas, Xiang Yufei, Fisher Logan, Hagin David, Sommer Karen, Song Yumei, Yang Soo Jung, Lopez Christina, Tappen Tori, Dam Elizabeth M, Khan Iram, Hale Malika, Buckner Jane H, Scharenberg Andrew M, Torgerson Troy R, Rawlings David J
Abstract excerpt
Thymic regulatory T cells (tTregs) are potent inhibitors of autoreactive immune responses, and loss of tTreg function results in fatal autoimmune disease. Defects in tTreg number or function are also implicated in multiple autoimmune diseases, leading to growing interest in use of Treg as cell therapies to establish immune tolerance. Because tTregs are present at low numbers in circulating blood and may be...
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