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Article

Naive precursors of human regulatory T cells require FoxP3 for suppression and are susceptible to HIV infection.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2008

Antons Amanda K, Wang Rui, Oswald-Richter Kyra, Tseng Michelle, Arendt Christopher W, Kalams Spyros A, Unutmaz Derya

Abstract excerpt

CD4+CD25+ human regulatory T cells (Treg cells), which express the transcription factor FoxP3, suppress T cell activation. In this study, we sought to define cellular and molecular mechanisms of human Treg cell differentiation. A subset of human naive CD4+ T cells that are CD25+ express high levels of FoxP3. We show that upon activation through the TCR, these FoxP3-expressing naive T cells (termed TNreg cells)...

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Identifiers

PMID: 18178814
DOI: 10.4049/jimmunol.180.2.764

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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