Identification and In Vitro Expansion of Functional Antigen-Specific CD25 ⁺ FoxP3 ⁺ Regulatory T Cells in Hepatitis C Virus Infection

Abstract excerpt

CD4(+)CD25(+) regulatory T cells (CD25(+) Tregs) play a key role in immune regulation. Since hepatitis C virus (HCV) persists with increased circulating CD4(+)CD25(+) T cells and virus-specific effector T-cell dysfunction, we asked if CD4(+)CD25(+) T cells in HCV-infected individuals are similar to natural Tregs in uninfected individuals and if they include HCV-specific Tregs using the specific Treg marker FoxP3...

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