Loss of methylation activates Xist in somatic but not in embryonic cells.

doi:10.1101/gad.9.19.2325

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Article

Loss of methylation activates Xist in somatic but not in embryonic cells.

Genes & development - 1 Oct 1995

Beard C, Li E, Jaenisch R

Abstract excerpt

The mouse Xist gene, which is expressed only from the inactive X chromosome, is thought to play a role in the initiation of X inactivation. The 5' end of this gene is fully methylated on the active X chromosome and completely demethylated on the inactive X chromosome, suggesting that DNA methylat...

Topics

Animals
Base Sequence
Blotting, Southern
Cell Differentiation
Cell Line
DNA Modification Methylases
DNA Primers
Embryo, Mammalian
Female
Gene Expression Regulation, Developmental
Genotype
Homozygote
Male
Methylation
Mice
Molecular Sequence Data
Mutation
RNA, Long Noncoding

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