Loss of methylation activates Xist in somatic but not in embryonic cells.

Abstract excerpt

The mouse Xist gene, which is expressed only from the inactive X chromosome, is thought to play a role in the initiation of X inactivation. The 5' end of this gene is fully methylated on the active X chromosome and completely demethylated on the inactive X chromosome, suggesting that DNA methylation may be involved in controlling allele-specific transcription of this gene. To directly investigate the importance...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Base Sequence
• Share to Blotting, Southern
• Share to Cell Line