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Article

A developmental switch in H4 acetylation upstream of Xist plays a role in X chromosome inactivation.

The EMBO journal - 17 May 1999

O'Neill L P, Keohane A M, Lavender J S, McCabe V, Heard E, Avner P, Brockdorff N, Turner B M

Abstract excerpt

We have investigated the role of histone acetylation in X chromosome inactivation, focusing on its possible involvement in the regulation of Xist, an essential gene expressed only from the inactive X (Xi). We have identified a region of H4 hyperacetylation extending up to 120 kb upstream from the Xist somatic promoter P1. This domain includes the promoter P0, which gives rise to the unstable Xist transcript in...

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Share to Acetylation
Share to Chromatin
Share to Dosage Compensation, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histone Deacetylase Inhibitors

Share to Hydroxamic Acids

Share to RNA, Long Noncoding

Share to RNA, Untranslated

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Identifiers

PMID: 10329635
DOI: 10.1093/emboj/18.10.2897
PMCID: PMC1171370

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A developmental switch in H4 acetylation upstream of Xist plays a role in X chromosome inactivation.PMID 10329635Read ↗

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