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Article

Role of histone H3 lysine 27 methylation in X inactivation.

Science (New York, N.Y.) - 4 Apr 2003

Plath Kathrin, Fang Jia, Mlynarczyk-Evans Susanna K, Cao Ru, Worringer Kathleen A, Wang Hengbin, de la Cruz Cecile C, Otte Arie P, Panning Barbara, Zhang Yi

Abstract excerpt

The Polycomb group (PcG) protein Eed is implicated in regulation of imprinted X-chromosome inactivation in extraembryonic cells but not of random X inactivation in embryonic cells. The Drosophila homolog of the Eed-Ezh2 PcG protein complex achieves gene silencing through methylation of histone H3 on lysine 27 (H3-K27), which suggests a role for H3-K27 methylation in imprinted X inactivation. Here we demonstrate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12649488
DOI: 10.1126/science.1084274

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Role of histone H3 lysine 27 methylation in X inactivation.PMID 12649488Read ↗

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A model for transmission of the H3K27me3 epigenetic mark.Semantic proximity Read ↗

A chromosomal memory triggered by Xist regulates histone methylation in X inactivation.Semantic proximity Read ↗

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Trans- and cis-acting effects of Firre on epigenetic features of the inactive X chromosome.Semantic proximity Read ↗

Genome imprinting regulated by the mouse Polycomb group protein Eed.Semantic proximity Read ↗

Full methylation of H3K27 by PRC2 is dispensable for initial embryoid body formation but required to maintain differentiated cell identity.Semantic proximity Read ↗

SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex.Semantic proximity Read ↗

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Differential histone H3 Lys-9 and Lys-27 methylation profiles on the X chromosome.Semantic proximity Read ↗

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