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Article

Activated polyamine catabolism depletes acetyl-CoA pools and suppresses prostate tumor growth in TRAMP mice.

The Journal of biological chemistry - 17 Sept 2004

Kee Kristin, Foster Barbara A, Merali Salim, Kramer Debora L, Hensen Mary L, Diegelman Paula, Kisiel Nicholas, Vujcic Slavoljub, Mazurchuk Richard V, Porter Carl W

Abstract excerpt

The enzyme spermidine/spermine N(1)-acetyltransferase (SSAT) regulates the catabolism and export of intracellular polyamines. We have previously shown that activation of polyamine catabolism by conditional overexpression of SSAT has antiproliferative consequences in LNCaP prostate carcinoma cells. Growth inhibition was causally linked to high metabolic flux arising from a compensatory increase in polyamine...

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Identifiers

PMID: 15252047
DOI: 10.1074/jbc.M406002200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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