Overexpression of spermidine/spermine N1-acetyltransferase impairs osteoblastogenesis and alters mouse bone phenotype.

doi:10.1007/s11248-014-9836-6

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Article

Overexpression of spermidine/spermine N1-acetyltransferase impairs osteoblastogenesis and alters mouse bone phenotype.

Transgenic research - 1 Apr 2015

Pirnes-Karhu Sini, Määttä Jorma, Finnilä Mikko, Alhonen Leena, Uimari Anne

Abstract excerpt

Spermidine/spermine N (1)-acetyltransferase (SSAT) is a catabolic regulator of polyamines, ubiquitous molecules essential for cell proliferation and differentiation. In pathological conditions, the increased polyamine catabolism has been shown to mediate its cellular functions not only by changed polyamine levels but also by the availability of metabolites shared with other metabolic pathways or by production of...

Topics

Acetyltransferases
Animals
Animals, Genetically Modified
Bone Development
Bone Remodeling
Kyphosis
Mice
Osteoblasts
Phenotype
Polyamines

Source

Open in PubMed

Identifiers

PMID: 25231394
DOI: 10.1007/s11248-014-9836-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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