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Article

Polyamine Antagonist Therapies Inhibit Neuroblastoma Initiation and Progression

24 Mar 2016

Abstract excerpt

PURPOSE: Deregulated MYC drives oncogenesis in many tissues yet direct pharmacologic inhibition has proven difficult. MYC coordinately regulates polyamine homeostasis as these essential cations support MYC functions, and drugs that antagonize polyamine sufficiency have synthetic-lethal interactions with MYC Neuroblastoma is a lethal tumor in which the MYC homologue MYCN, and ODC1, the rate-limiting enzyme in...

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PMID: 27012811
DOI: 10.1158/1078-0432.ccr-15-2539

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