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Mild folate deficiency induces genetic and epigenetic instability and phenotype changes in prostate cancer cells

21 Jan 2010

Abstract excerpt

BACKGROUND: Folate (vitamin B9) is essential for cellular proliferation as it is involved in the biosynthesis of deoxythymidine monophosphate (dTMP) and s-adenosylmethionine (AdoMet). The link between folate depletion and the genesis and progression of cancers of epithelial origin is of high clinical relevance, but still unclear. We recently demonstrated that sensitivity to low folate availability is affected by...

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PMID: 20092614
DOI: 10.1186/1741-7007-8-6

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