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Article

Transgenic animals modelling polyamine metabolism-related diseases.

Essays in biochemistry - 4 Nov 2009

Alhonen Leena, Uimari Anne, Pietilä Marko, Hyvönen Mervi T, Pirinen Eija, Keinänen Tuomo A

Abstract excerpt

Cloning of genes related to polyamine metabolism has enabled the generation of genetically modified mice and rats overproducing or devoid of proteins encoded by these genes. Our first transgenic mice overexpressing ODC (ornithine decarboxylase) were generated in 1991 and, thereafter, most genes involved in polyamine metabolism have been used for overproduction of the respective proteins, either ubiquitously or in...

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Identifiers

PMID: 20095974
DOI: 10.1042/bse0460009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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