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Article

Genetic manipulation of polyamine catabolism in rodents.

Journal of biochemistry - 1 Feb 2006

Jänne Juhani, Alhonen Leena, Pietilä Marko, Keinänen Tuomo A, Uimari Anne, Hyvönen Mervi T, Pirinen Eija, Järvinen Aki

Abstract excerpt

Activation of polyamine catabolism through the overexpression of spermidine/spermine N1-acetyltransferase (SSAT) in transgenic rodents does not only lead to distorted tissue polyamine homeostasis, manifested as striking accumulation of putrescine, appearance N1-acetylspermidine and reduction of tissue spermidine and/or spermine pools, but likewise creates striking phenotypic changes. The latter include loss of...

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PMID: 16452302
DOI: 10.1093/jb/mvj035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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