Genetic manipulation of polyamine catabolism in rodents.

doi:10.1093/jb/mvj035

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Article

Genetic manipulation of polyamine catabolism in rodents.

Journal of biochemistry - 1 Feb 2006

Jänne Juhani, Alhonen Leena, Pietilä Marko, Keinänen Tuomo A, Uimari Anne, Hyvönen Mervi T, Pirinen Eija, Järvinen Aki

Abstract excerpt

Activation of polyamine catabolism through the overexpression of spermidine/spermine N1-acetyltransferase (SSAT) in transgenic rodents does not only lead to distorted tissue polyamine homeostasis, manifested as striking accumulation of putrescine, appearance N1-acetylspermidine and reduction of tissue spermidine and/or spermine pools, but likewise creates striking phenotypic changes. The latter include loss of...

Topics

Acetyltransferases
Animals
Animals, Genetically Modified
Gene Expression Regulation
Gene Transfer Techniques
Genetic Predisposition to Disease
Mice
Neoplasms
Polyamines
Rats

Source

Open in PubMed

Identifiers

PMID: 16452302
DOI: 10.1093/jb/mvj035

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