Article
Genetically altered expression of spermidine/spermine N1-acetyltransferase affects fat metabolism in mice via acetyl-CoA.
The Journal of biological chemistry - 16 Mar 2007
Jell Jason, Merali Salim, Hensen Mary L, Mazurchuk Richard, Spernyak Joseph A, Diegelman Paula, Kisiel Nicholas D, Barrero Carlos, Deeb Kristin K, Alhonen Leena, Patel Mulchand S, Porter Carl W
Abstract excerpt
The acetylating enzyme, spermidine/spermine N1-acetyltransferase, participates in polyamine homeostasis by regulating polyamine export and catabolism. Previously, we reported that overexpression of the enzyme in cultured tumor cells and mice activates metabolic flux through the polyamine pathway and depletes the N1-acetyltransferase coenzyme and fatty acid precursor, acetyl-CoA. Here, we investigate this...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.