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Article

Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis.

Carcinogenesis - 1 Feb 2002

Coleman Catherine S, Pegg Anthony E, Megosh Louis C, Guo Yongjun, Sawicki Janet A, O'Brien Thomas G

Abstract excerpt

The bovine keratin 6 gene promoter was used to target expression of spermidine/spermine N1-acetyltransferase (SSAT) to epidermal keratinocytes in the hair follicle of transgenic mice. K6-SSAT transgenic mice appeared to be phenotypically normal and were indistinguishable from normal littermates until subjected to a two-stage tumorigenesis protocol. For such tumorigenesis studies, mice were bred for six...

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Identifiers

PMID: 11872645
DOI: 10.1093/carcin/23.2.359

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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