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Article

Gene expression profiles at diagnosis in de novo childhood AML patients identify FLT3 mutations with good clinical outcomes.

Blood - 1 Nov 2004

Lacayo Norman J, Meshinchi Soheil, Kinnunen Paivi, Yu Ron, Wang Yan, Stuber Christianna M, Douglas Lorrie, Wahab Romina, Becton David L, Weinstein Howard, Chang Myron N, Willman Cheryl L, Radich Jerald P, Tibshirani Robert, Ravindranath Yaddanapudi, Sikic Branimir I, Dahl Gary V

Abstract excerpt

Fms-like tyrosine kinase 3 (FLT3) mutations are associated with unfavorable outcomes in children with acute myeloid leukemia (AML). We used DNA microarrays to identify gene expression profiles related to FLT3 status and outcome in childhood AML. Among 81 diagnostic specimens, 36 had FLT3 mutations (FLT3-MUs), 24 with internal tandem duplications (ITDs) and 12 with activating loop mutations (ALMs). In addition, 8...

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Source

Identifiers

PMID: 15251987
DOI: 10.1182/blood-2003-12-4449

Genes

FLT3
ATRX
RUNX3
EFS
PAM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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