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Article

An FLT3 gene-expression signature predicts clinical outcome in normal karyotype AML

29 Feb 2008

Abstract excerpt

Acute myeloid leukemia with normal karyotype (NK-AML) represents a cytogenetic grouping with intermediate prognosis but substantial molecular and clinical heterogeneity. Within this subgroup, presence of FLT3 (FMS-like tyrosine kinase 3) internal tandem duplication (ITD) mutation predicts less favorable outcome. The goal of our study was to discover gene-expression patterns correlated with FLT3-ITD mutation and...

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Identifiers

PMID: 18309032
DOI: 10.1182/blood-2007-09-115055

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