FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications.

doi:10.1182/blood-2007-08-107946

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FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications.

Blood - 1 Feb 2008

Whitman Susan P, Ruppert Amy S, Radmacher Michael D, Mrózek Krzysztof, Paschka Peter, Langer Christian, Baldus Claudia D, Wen Jing, Racke Frederick, Powell Bayard L, Kolitz Jonathan E, Larson Richard A, Caligiuri Michael A, Marcucci Guido, Bloomfield Clara D

Abstract excerpt

The prognostic relevance of FLT3 D835/I836 mutations (FLT3-TKD) in cytogenetically normal acute myeloid leukemia (CN-AML) remains to be established. After excluding patients with FLT3 internal tandem duplications, we compared treatment outcome of 16 de novo CN-AML patients with FLT3-TKD with that of 123 patients with wild-type FLT3 (FLT3-WT), less than 60 years of age and similarly treated on Cancer and Leukemia...

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Identifiers

PMID: 17940205
DOI: 10.1182/blood-2007-08-107946
PMCID: PMC2214747

Genes

FLT3
NPM1
PTPN6
VNN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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