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Article

Crosstalk between genomic variants and DNA methylation in FLT3 mutant acute myeloid leukemia.

Briefings in functional genomics - 15 Jan 2025

Dao Bac, Trinh Van Ngu, Nguyen Huy V, Nguyen Hoa L, Le Thuc Duy, Luu Phuc Loi

Abstract excerpt

Acute myeloid leukemia (AML) is a type of blood cancer with diverse genetic variations and DNA methylation alterations. By studying the interaction of gene mutations, expression, and DNA methylation, we aimed to gain valuable insights into the processes that lead to block differentiation in AML. We analyzed TCGA-LAML data (173 samples) with RNA sequencing and DNA methylation arrays, comparing FLT3 mutant (48) and...

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Topics

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Share to DNA Methylation
Share to fms-Like Tyrosine Kinase 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to FLT3 gene

Share to TET2 gene

Share to WT1 gene

Share to Leukemia, Myeloid, Acute

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Source

Open in PubMed Open full text

Identifiers

PMID: 38944027
DOI: 10.1093/bfgp/elae028
PMCID: PMC11735749

Genes

FLT3
WT1
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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