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Upregulation of FHL1, SPNS3, and MPZL2 predicts poor prognosis in pediatric acute myeloid leukemia patients with FLT3-ITD mutation.

Leukemia & lymphoma - 1 Aug 2022

Eshibona Nasr, Giwa Abdulazeez, Rossouw Sophia Catherine, Gamieldien Junaid, Christoffels Alan, Bendou Hocine

Abstract excerpt

Chromosomal translocations and gene mutations are characteristics of the genomic profile of acute myeloid leukemia (AML). We aim to identify a gene signature associated with poor prognosis in AML patients with FLT3-ITD compared to AML patients with NPM1/CEBPA mutations. RNA-sequencing (RNA-Seq) count data were downloaded from the UCSC Xena browser. Samples were grouped by their mutation status into high and...

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PMID: 35249471
DOI: 10.1080/10428194.2022.2045594

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