Disease Characteristics and Prognostic Implications of Cell-Surface FLT3 Receptor (CD135) Expression in Pediatric Acute Myeloid Leukemia: A Report from the Children's Oncology Group.

doi:10.1158/1078-0432.CCR-16-2353

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Article

Disease Characteristics and Prognostic Implications of Cell-Surface FLT3 Receptor (CD135) Expression in Pediatric Acute Myeloid Leukemia: A Report from the Children's Oncology Group.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Jul 2017

Tarlock Katherine, Alonzo Todd A, Loken Michael R, Gerbing Robert B, Ries Rhonda E, Aplenc Richard, Sung Lillian, Raimondi Susana C, Hirsch Betsy A, Kahwash Samir B, McKenney Amy, Kolb E Anders, Gamis Alan S, Meshinchi Soheil

Abstract excerpt

Purpose: The FLT3 cell-surface receptor tyrosine kinase (CD135) is expressed in a majority of both acute lymphoid leukemia (ALL) and myeloid leukemia (AML). However, the prognostic significance of CD135 expression in AML remains unclear. We therefore evaluated the association between FLT3 surface expression and disease characteristics and outcomes in pediatric patients with AML.Experimental Design: We analyzed...

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PMID: 28108543
DOI: 10.1158/1078-0432.CCR-16-2353
PMCID: PMC5511553

Genes

FLT3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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