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Article

FLT3-ITD-associated gene-expression signatures in NPM1-mutated cytogenetically normal acute myeloid leukemia.

International journal of hematology - 1 Aug 2012

Huang Liang, Zhou Kuangguo, Yang Yunfan, Shang Zhen, Wang Jue, Wang Di, Wang Na, Xu Danmei, Zhou Jianfeng

Abstract excerpt

Concomitance of the FLT3-ITD mutation is associated with poor prognosis in NPM1-mutated cytogenetically normal acute myeloid leukemia (CN-AML) patients, and precise studies on its role in leukemogenesis are needed; these may be elucidated at the molecular level by gene express profiling. In the present study, we built a gene-expression-based classifier using prediction analysis of microarray to characterize the...

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Source

Identifiers

PMID: 22688855
DOI: 10.1007/s12185-012-1115-9

Genes

NPM1
FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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