Gene expression profiling identifies FLT3 mutation-like cases in wild-type FLT3 acute myeloid leukemia.

doi:10.1371/journal.pone.0247093

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Article

Gene expression profiling identifies FLT3 mutation-like cases in wild-type FLT3 acute myeloid leukemia.

PloS one - 1 Jan 2021

Mosquera Orgueira Adrián, Peleteiro Raíndo Andrés, Cid López Miguel, Antelo Rodríguez Beatriz, Díaz Arias José Ángel, Ferreiro Ferro Roi, Alonso Vence Natalia, Bendaña López Ángeles, Abuín Blanco Aitor, Bao Pérez Laura, Melero Valentín Paula, González Pérez Marta Sonia, Cerchione Claudio, Martinelli Giovanni, Montesinos Fernández Pau, Pérez Encinas Manuel Mateo, Bello López José Luis

Abstract excerpt

BACKGROUND: FLT3 mutation is present in 25-30% of all acute myeloid leukemias (AML), and it is associated with adverse outcome. FLT3 inhibitors have shown improved survival results in AML both as upfront treatment and in relapsed/refractory disease. Curiously, a variable proportion of wild-type FLT3 patients also responded to these drugs. METHODS: We analyzed 6 different transcriptomic datasets of AML cases....

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PMID: 33592069
DOI: 10.1371/journal.pone.0247093
PMCID: PMC7886212

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