Article
Distinct gene expression patterns associated with FLT3- and NRAS-activating mutations in acute myeloid leukemia with normal karyotype.
Oncogene - 24 Feb 2005
Neben Kai, Schnittger Susanne, Brors Benedikt, Tews Björn, Kokocinski Felix, Haferlach Torsten, Müller Jasmin, Hahn Meinhard, Hiddemann Wolfgang, Eils Roland, Lichter Peter, Schoch Claudia
Abstract excerpt
In acute myeloid leukemia (AML), constitutive activation of the FLT3 receptor tyrosine kinase, either by internal tandem duplications (FLT3-ITD) of the juxtamembrane region or by point mutations in the second tyrosine kinase domain (FLT3-TKD), as well as point mutations of the NRAS gene (NRAS-PM) are among the most frequent somatic gene mutations. To elucidate whether these mutations cause aberrant signal...
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