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Article

Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity.

Diabetologia - 1 Jul 2004

Gylvin T, Nolsøe R, Hansen T, Nielsen E M D, Bergholdt R, Karlsen A E, Billestrup N, Borch-Johnsen K, Pedersen O, Mandrup-Poulsen T, Nerup J, Pociot F

Abstract excerpt

AIMS/HYPOTHESIS: Beta cell loss in Type 1 and Type 2 diabetes mellitus may result from apoptosis and necrosis induced by inflammatory mediators. The suppressor of cytokine signalling (SOCS)-3 is a natural inhibitor of cytokine signalling and also influences insulin signalling. SOCS3 could therefore be a candidate gene in the development of Type 1 and Type 2 diabetes mellitus. METHODS: Mutation analysis of the...

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Identifiers

PMID: 15249995
DOI: 10.1007/s00125-004-1440-5

Genes

SOCS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity.PMID 15249995Read ↗

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Analysis of sequence variations in the suppressor of cytokine signaling (SOCS)-3 gene in extremely obese children and adolescents.Semantic proximity Read ↗

Common polymorphisms in SOCS3 are not associated with body weight, insulin sensitivity or lipid profile in normal female twins.Semantic proximity Read ↗

Association study of polymorphisms in SOCS family genes with type 1 diabetes mellitus.Semantic proximity Read ↗

Suppressor of cytokine signaling 3 is a physiological regulator of adipocyte insulin signaling.Semantic proximity Read ↗

Polymorphisms near SOCS3 are associated with obesity and glucose homeostasis traits in Hispanic Americans from the Insulin Resistance Atherosclerosis Family Study.Semantic proximity Read ↗

Association of suppressor of cytokine signalling 3 polymorphisms with insulin resistance in patients with chronic hepatitis C.Semantic proximity Read ↗

Suppressor of cytokine signaling gene expression in human pancreatic islets: modulation by cytokinesSemantic proximity Read ↗

SKAP2, a Candidate Gene for Type 1 Diabetes, Regulates β-Cell Apoptosis and Glycemic Control in Newly Diagnosed Patients.Semantic proximity Read ↗

Effect of Cytokine Signaling 3 Gene Polymorphisms in Childhood Obesity.Semantic proximity Read ↗

Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance.Semantic proximity Read ↗

Computational analysis of functional, structural and pathogenic impacts of missense SNPs in the human SOCS3 gene.Semantic proximity Read ↗

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