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Article

Common polymorphisms in SOCS3 are not associated with body weight, insulin sensitivity or lipid profile in normal female twins.

Diabetologia - 1 Feb 2006

Jamshidi Y, Snieder H, Wang X, Spector T D, Carter N D, O'Dell S D

Abstract excerpt

AIMS/HYPOTHESIS: Inhibition of signal transduction by suppressor of cytokine signalling-3 (SOCS-3) potentially influences resistance to insulin and leptin. The aim of this study was to test the association between three single-nucleotide polymorphisms (SNPs) representative of common linkage disequilibrium clusters in SOCS3 (rs4969169, rs12953258 and rs8064821) and obesity measures, insulin sensitivity measures...

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Source

Open in PubMed Open full text

Identifiers

PMID: 16402267
DOI: 10.1007/s00125-005-0093-3
PMCID: PMC1364534

Genes

SOCS3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Common polymorphisms in SOCS3 are not associated with body weight, insulin sensitivity or lipid profile in normal female twins.PMID 16402267Read ↗

Common STAT3 variants are not associated with obesity or insulin resistance in female twins.Semantic proximity Read ↗

Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance.Semantic proximity Read ↗

Lack of association between the tagging SNP A+930-->G of SOCS3 and type 2 diabetes mellitus: meta-analysis of four independent study populations.Semantic proximity Read ↗

Analysis of sequence variations in the suppressor of cytokine signaling (SOCS)-3 gene in extremely obese children and adolescents.Semantic proximity Read ↗

Polymorphisms near SOCS3 are associated with obesity and glucose homeostasis traits in Hispanic Americans from the Insulin Resistance Atherosclerosis Family Study.Semantic proximity Read ↗

Study of genetic variation in the STAT3 on obesity and insulin resistance in male adults.Semantic proximity Read ↗

Association of common JAK2 variants with body fat, insulin sensitivity and lipid profile.Semantic proximity Read ↗

Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity.Semantic proximity Read ↗

Effect of Cytokine Signaling 3 Gene Polymorphisms in Childhood Obesity.Semantic proximity Read ↗

[Association of SOCS3 gene polymorphisms with insulin resistance in Xinjiang Uygur population].Semantic proximity Read ↗

Obesity is associated with IL-6 gene polymorphisms rs1800795 and rs1800796 but not SOCS3 rs4969170.Semantic proximity Read ↗

Phosphatidylinositol 3-kinase p85alpha regulatory subunit gene PIK3R1 haplotype is associated with body fat and serum leptin in a female twin population.Semantic proximity Read ↗

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