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Article

Polymorphisms near SOCS3 are associated with obesity and glucose homeostasis traits in Hispanic Americans from the Insulin Resistance Atherosclerosis Family Study.

Human genetics - 1 Mar 2009

Talbert Matthew E, Langefeld Carl D, Ziegler Julie, Mychaleckyj Josyf C, Haffner Steven M, Norris Jill M, Bowden Donald W

Abstract excerpt

The SOCS3 gene product participates in the feedback inhibition of a range of cytokine signals. Most notably, SOCS3 inhibits the functioning of leptin and downstream steps in insulin signaling after being expressed by terminal transcription factors, such as STAT3 and c-fos. The SOCS3 gene is locat...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19083014
DOI: 10.1007/s00439-008-0608-3
PMCID: PMC2804661

Genes

SOCS3
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19083014-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Polymorphisms near SOCS3 are associated with obesity and glucose homeostasis traits in Hispanic Americans from the Insulin Resistance Atherosclerosis Family Study.PMID 19083014Read ↗

Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance.Semantic proximity Read ↗

Lack of association between the tagging SNP A+930-->G of SOCS3 and type 2 diabetes mellitus: meta-analysis of four independent study populations.Semantic proximity Read ↗

Common polymorphisms in SOCS3 are not associated with body weight, insulin sensitivity or lipid profile in normal female twins.Semantic proximity Read ↗

Mendelian Randomization Analysis of the Association of SOCS3 Methylation with Abdominal Obesity.Semantic proximity Read ↗

Epigenome-wide association analysis revealed that SOCS3 methylation influences the effect of cumulative stress on obesitySemantic proximity Read ↗

Analysis of sequence variations in the suppressor of cytokine signaling (SOCS)-3 gene in extremely obese children and adolescents.Semantic proximity Read ↗

Genetic mapping of a 17q chromosomal region linked to obesity phenotypes in the IRAS family study.Semantic proximity Read ↗

INSIG2 SNPs associated with obesity and glucose homeostasis traits in Hispanics: the IRAS Family Study.Semantic proximity Read ↗

Genome-wide association study and follow-up analysis of adiposity traits in Hispanic Americans: the IRAS Family Study.Semantic proximity Read ↗

Association of two polymorphisms within and near SOCS3 gene with obesity in three nationalities in Xinjiang province of China.Semantic proximity Read ↗

Identification of SOCS-3 as a Potential Mediator of Central Leptin ResistanceSemantic proximity Read ↗

Effect of Cytokine Signaling 3 Gene Polymorphisms in Childhood Obesity.Semantic proximity Read ↗

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