Lack of association between the tagging SNP A+930-->G of SOCS3 and type 2 diabetes mellitus: meta-analysis of four independent study populations.

doi:10.1371/journal.pone.0003852

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Article

Lack of association between the tagging SNP A+930-->G of SOCS3 and type 2 diabetes mellitus: meta-analysis of four independent study populations.

PloS one - 1 Jan 2008

Fischer-Rosinsky Antje, Fisher Eva, Kovacs Peter, Blüher Matthias, Möhlig Matthias, Pfeiffer Andreas F H, Boeing Heiner, Spranger Joachim

Abstract excerpt

BACKGROUND: The suppressor of cytokine signalling 3 (SOCS3) provides a link between cytokine action and their negative consequences on insulin signalling. Thus SOCS3 is a potential candidate gene for type 2 diabetes (T2DM). METHODOLOGY/PRINCIPAL FINDINGS: Based on HapMap we identified the polymorphism A+930-->G (rs4969168) as a haplotype tagging SNP (htSNP) sufficiently covering the genetic variation of the whole...

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PMID: 19052638
DOI: 10.1371/journal.pone.0003852
PMCID: PMC2585796

Genes

SOCS3

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