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Article

Analysis of sequence variations in the suppressor of cytokine signaling (SOCS)-3 gene in extremely obese children and adolescents.

BMC medical genetics - 19 Apr 2007

Hölter Katja, Wermter Anne-Kathrin, Scherag André, Siegfried Wolfgang, Goldschmidt Hanspeter, Hebebrand Johannes, Hinney Anke

Abstract excerpt

BACKGROUND: The suppressor of cytokine signaling (SOCS)-3 is a negative feedback regulator of cytokine signaling and also influences leptin signaling. We investigated association of variations in the coding sequence and promoter region of SOCS3 with extreme obesity in German children and adolesce...

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Source

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Identifiers

PMID: 17445271
DOI: 10.1186/1471-2350-8-21
PMCID: PMC1866222

Genes

SOCS3
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17445271-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Analysis of sequence variations in the suppressor of cytokine signaling (SOCS)-3 gene in extremely obese children and adolescents.PMID 17445271Read ↗

Effect of Cytokine Signaling 3 Gene Polymorphisms in Childhood Obesity.Semantic proximity Read ↗

Common polymorphisms in SOCS3 are not associated with body weight, insulin sensitivity or lipid profile in normal female twins.Semantic proximity Read ↗

Lack of association between the tagging SNP A+930-->G of SOCS3 and type 2 diabetes mellitus: meta-analysis of four independent study populations.Semantic proximity Read ↗

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Mutation analysis of suppressor of cytokine signalling 3, a candidate gene in Type 1 diabetes and insulin sensitivity.Semantic proximity Read ↗

Obesity is associated with IL-6 gene polymorphisms rs1800795 and rs1800796 but not SOCS3 rs4969170.Semantic proximity Read ↗

Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance.Semantic proximity Read ↗

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Computational analysis of functional, structural and pathogenic impacts of missense SNPs in the human SOCS3 gene.Semantic proximity Read ↗

The STK33-linked SNP rs4929949 is associated with obesity and BMI in two independent cohorts of Swedish and Greek children.Semantic proximity Read ↗

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