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Article

Computational analysis of functional, structural and pathogenic impacts of missense SNPs in the human SOCS3 gene.

Mutation research - 1 Jan 2026

Alipeddi Raviteja Reddy, Rani Durga Neeharika, Sampanmudumby Pallavi, Hanumanth Surekha Rani

Abstract excerpt

The Suppressor of Cytokine Signaling 3 (SOCS3) protein is a crucial negative regulator of cytokine-mediated signaling pathways, and genetic variations in SOCS3 have been implicated in the development of multiple multi-factorial diseases (MFDs). In this study, a comprehensive insilico analysis was performed to evaluate the functional and structural consequences of eight missense single nucleotide polymorphisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41401744
DOI: 10.1016/j.mrfmmm.2025.111925

Genes

SOCS3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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