Article
The PDZ domain of PICK1 differentially accepts protein kinase C-alpha and GluR2 as interacting ligands.
The Journal of biological chemistry - 1 Oct 2004
Dev Kumlesh K, Nakanishi Shigetada, Henley Jeremy M
Abstract excerpt
The C terminus (ct) of protein kinase C-alpha (PKCalpha) has a type I PDZ binding motif, whereas GluR2 has a type II PDZ binding motif. Both motifs are recognized by the PDZ domain of protein interacting with protein kinase C (PICK1), and PICK1-PKCalpha-controlled phosphorylation regulates the synaptic expression and function of GluR2. Here, we show that a specific mutation within the carboxylate-binding loop of...
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