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Article

The binding affinities of proteins interacting with the PDZ domain of PICK1.

Proteins - 1 May 2012

Bolia Ashini, Gerek Z Nevin, Keskin Ozlem, Banu Ozkan Sefika, Dev Kumlesh K

Abstract excerpt

Protein interacting with C kinase (PICK1) is well conserved throughout evolution and plays a critical role in synaptic plasticity by regulating the trafficking and posttranslational modification of its interacting proteins. PICK1 contains a single PSD95/DlgA/Zo-1 (PDZ) protein-protein interaction domain, which is promiscuous and shown to interact with over 60 proteins, most of which play roles in neuronal...

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Source

Identifiers

PMID: 22275068
DOI: 10.1002/prot.24034

Genes

PICK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The binding affinities of proteins interacting with the PDZ domain of PICK1.PMID 22275068Read ↗

Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/discs-large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands.Semantic proximity Read ↗

AMPA GluA2 subunit competitive inhibitors for PICK1 PDZ domain: Pharmacophore-based virtual screening, molecular docking, molecular dynamic simulation, and ADME studiesSemantic proximity Read ↗

Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes.Semantic proximity Read ↗

Lipid binding regulates synaptic targeting of PICK1, AMPA receptor trafficking, and synaptic plasticity.Semantic proximity Read ↗

Serine 77 in the PDZ domain of PICK1 is a protein kinase Cα phosphorylation site regulated by lipid membrane binding.Semantic proximity Read ↗

The PDZ domain of PICK1 differentially accepts protein kinase C-alpha and GluR2 as interacting ligands.Semantic proximity Read ↗

Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1.Semantic proximity Read ↗

PICK1 links KIBRA and AMPA receptors in coiled-coil-driven supramolecular complexesSemantic proximity Read ↗

Molecular determinants for PICK1 synaptic aggregation and mGluR7a receptor coclustering: role of the PDZ, coiled-coil, and acidic domains.Semantic proximity Read ↗

Interaction of the synaptic protein PICK1 (protein interacting with C kinase 1) with the non-voltage gated sodium channels BNC1 (brain Na+ channel 1) and ASIC (acid-sensing ion channel).Semantic proximity Read ↗

The schizophrenic faces of PICK1.Semantic proximity Read ↗

A molecular-properties-based approach to understanding PDZ domain proteins and PDZ ligands.Semantic proximity Read ↗

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