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Article

Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 8 Dec 2010

Citri Ami, Bhattacharyya Samarjit, Ma Cong, Morishita Wade, Fang Scarlett, Rizo Josep, Malenka Robert C

Abstract excerpt

NMDA receptor (NMDAR)-dependent long-term depression (LTD) in the hippocampus is mediated primarily by the calcium-dependent removal of AMPA receptors (AMPARs) from the postsynaptic density. The AMPAR-binding, PDZ (PSD-95/Dlg/ZO1) and BAR (Bin/amphiphysin/Rvs) domain-containing protein PICK1 has been implicated in the regulation of AMPAR trafficking underlying several forms of synaptic plasticity. Using a...

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Source

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Identifiers

PMID: 21147983
DOI: 10.1523/JNEUROSCI.4478-10.2010
PMCID: PMC3004477

Genes

PICK1
PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression.PMID 21147983Read ↗

Lipid binding regulates synaptic targeting of PICK1, AMPA receptor trafficking, and synaptic plasticity.Semantic proximity Read ↗

Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes.Semantic proximity Read ↗

PICK1 mediates transient synaptic expression of GluA2-lacking AMPA receptors during glycine-induced AMPA receptor trafficking.Semantic proximity Read ↗

PICK1 links KIBRA and AMPA receptors in coiled-coil-driven supramolecular complexesSemantic proximity Read ↗

Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression.Semantic proximity Read ↗

Molecular determinants for PICK1 synaptic aggregation and mGluR7a receptor coclustering: role of the PDZ, coiled-coil, and acidic domains.Semantic proximity Read ↗

Knock-in mice lacking the PDZ-ligand motif of mGluR7a show impaired PKC-dependent autoinhibition of glutamate release, spatial working memory deficits, and increased susceptibility to pentylenetetrazol.Semantic proximity Read ↗

AMPA-receptor specific biogenesis complexes control synaptic transmission and intellectual ability.Semantic proximity Read ↗

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SIPA1L1/SPAR1 is a non-PSD protein involved in GPCR signalingSemantic proximity Read ↗

The intellectual disability protein RAB39B selectively regulates GluA2 trafficking to determine synaptic AMPAR composition.Semantic proximity Read ↗

AMPA receptor trafficking and the mechanisms underlying synaptic plasticity and cognitive agingSemantic proximity Read ↗

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