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Article

Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes.

The EMBO journal - 31 Oct 2007

Pan Lifeng, Wu Hao, Shen Chong, Shi Yawei, Jin Wenying, Xia Jun, Zhang Mingjie

Abstract excerpt

Protein interacting with c kinase 1 (PICK1) regulates the trafficking of receptors and ion-channels such as AMPA receptors. Traditionally, the PICK1 PDZ domain is regarded as an adaptor capable of binding to receptors trafficked by PICK1, and the lipid-binding BAR domain functions to tether PICK1 directly to membranes. Here, we show that the PICK1 PDZ domain can directly interact with lipid membranes. The PDZ...

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Share to Carrier Proteins
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Share to Cluster Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytoskeletal Proteins

Share to Lipids

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Share to Receptors, AMPA

Share to Sequence Homology, Amino Acid

Source

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Identifiers

PMID: 17914463
DOI: 10.1038/sj.emboj.7601860
PMCID: PMC2063473

Genes

PICK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes.PMID 17914463Read ↗

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