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Article

Serine 77 in the PDZ domain of PICK1 is a protein kinase Cα phosphorylation site regulated by lipid membrane binding.

Biochemistry - 17 Jan 2012

Ammendrup-Johnsen Ina, Thorsen Thor S, Gether Ulrik, Madsen Kenneth L

Abstract excerpt

PICK1 (protein interacting with C kinase 1) contains an N-terminal protein binding PDZ domain and a C-terminal lipid binding BAR domain. PICK1 plays a key role in several physiological processes, including synaptic plasticity. However, little is known about the cellular mechanisms governing the activity of PICK1 itself. Here we show that PICK1 is a substrate in vitro both for PKCα (protein kinase Cα), as...

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Source

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Identifiers

PMID: 22129425
DOI: 10.1021/bi2014689
PMCID: PMC3312318

Genes

PICK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Serine 77 in the PDZ domain of PICK1 is a protein kinase Cα phosphorylation site regulated by lipid membrane binding.PMID 22129425Read ↗

Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes.Semantic proximity Read ↗

The PDZ domain of PICK1 differentially accepts protein kinase C-alpha and GluR2 as interacting ligands.Semantic proximity Read ↗

Lipid binding regulates synaptic targeting of PICK1, AMPA receptor trafficking, and synaptic plasticity.Semantic proximity Read ↗

Corequirement of PICK1 binding and PKC phosphorylation for stable surface expression of the metabotropic glutamate receptor mGluR7.Semantic proximity Read ↗

The binding affinities of proteins interacting with the PDZ domain of PICK1.Semantic proximity Read ↗

Protein interacting with C-kinase 1 (PICK1) binding promiscuity relies on unconventional PSD-95/discs-large/ZO-1 homology (PDZ) binding modes for nonclass II PDZ ligands.Semantic proximity Read ↗

Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1.Semantic proximity Read ↗

Knock-in mice lacking the PDZ-ligand motif of mGluR7a show impaired PKC-dependent autoinhibition of glutamate release, spatial working memory deficits, and increased susceptibility to pentylenetetrazol.Semantic proximity Read ↗

Molecular determinants for PICK1 synaptic aggregation and mGluR7a receptor coclustering: role of the PDZ, coiled-coil, and acidic domains.Semantic proximity Read ↗

PICK1 links KIBRA and AMPA receptors in coiled-coil-driven supramolecular complexesSemantic proximity Read ↗

Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression.Semantic proximity Read ↗

PICK1 links AMPA receptor stimulation to Cdc42.Semantic proximity Read ↗

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