Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lipid binding regulates synaptic targeting of PICK1, AMPA receptor trafficking, and synaptic plasticity.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Mar 2006

Jin Wenying, Ge Woo-Ping, Xu Junyu, Cao Mian, Peng Lisheng, Yung Wingho, Liao Dezhi, Duan Shumin, Zhang Mingjie, Xia Jun

Abstract excerpt

The targeting and surface expression of membrane proteins are critical to their functions. In neurons, synaptic targeting and surface expression of AMPA-type glutamate receptors were found to be critical for synaptic plasticity such as long-term potentiation and long-term depression (LTD). PICK1 (protein interacting with C kinase 1) is a cytosolic protein that interacts with many membrane proteins, including AMPA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biotinylation
Share to Disks Large Homolog 4 Protein

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electric Stimulation

Share to Immunoprecipitation

Share to Neuronal Plasticity

Share to Phosphatidylinositols

Share to Receptors, AMPA

Share to Subcellular Fractions

Source

Open in PubMed Open full text

Identifiers

PMID: 16510715
DOI: 10.1523/JNEUROSCI.3503-05.2006
PMCID: PMC6793652

Genes

PICK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lipid binding regulates synaptic targeting of PICK1, AMPA receptor trafficking, and synaptic plasticity.PMID 16510715Read ↗

Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes.Semantic proximity Read ↗

Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression.Semantic proximity Read ↗

Serine 77 in the PDZ domain of PICK1 is a protein kinase Cα phosphorylation site regulated by lipid membrane binding.Semantic proximity Read ↗

PICK1 mediates synaptic recruitment of AMPA receptors at neurexin-induced postsynaptic sites.Semantic proximity Read ↗

PICK1 links KIBRA and AMPA receptors in coiled-coil-driven supramolecular complexesSemantic proximity Read ↗

The PDZ domain of PICK1 differentially accepts protein kinase C-alpha and GluR2 as interacting ligands.Semantic proximity Read ↗

Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1.Semantic proximity Read ↗

The binding affinities of proteins interacting with the PDZ domain of PICK1.Semantic proximity Read ↗

PICK1 links AMPA receptor stimulation to Cdc42.Semantic proximity Read ↗

The intellectual disability protein RAB39B selectively regulates GluA2 trafficking to determine synaptic AMPAR composition.Semantic proximity Read ↗

Molecular determinants for PICK1 synaptic aggregation and mGluR7a receptor coclustering: role of the PDZ, coiled-coil, and acidic domains.Semantic proximity Read ↗

PICK1 expression in the Drosophila central nervous system primarily occurs in the neuroendocrine system.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.