Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular determinants for PICK1 synaptic aggregation and mGluR7a receptor coclustering: role of the PDZ, coiled-coil, and acidic domains.

The Journal of biological chemistry - 10 Aug 2001

Boudin H, Craig A M

Abstract excerpt

PSD-95/Disc-large/ZO-1 (PDZ) domain-containing proteins play a central role in synaptic organization by their involvement in neurotransmitter receptor clustering and signaling complex assembly. The protein interacting with protein kinase C (PICK1), a synaptic PDZ domain protein that also contains a coiled-coil and acidic domain, binds to several synaptic components including the metabotropic glutamate receptor...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytoskeletal Proteins
Share to DNA, Complementary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fibroblasts

Share to Hippocampus

Share to Immunoblotting

Share to Neurons

Share to Receptors, Metabotropic Glutamate

Share to Two-Hybrid System Techniques

Source

Identifiers

PMID: 11375398
DOI: 10.1074/jbc.M102991200

Genes

PICK1
PSD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular determinants for PICK1 synaptic aggregation and mGluR7a receptor coclustering: role of the PDZ, coiled-coil, and acidic domains.PMID 11375398Read ↗

Knock-in mice lacking the PDZ-ligand motif of mGluR7a show impaired PKC-dependent autoinhibition of glutamate release, spatial working memory deficits, and increased susceptibility to pentylenetetrazol.Semantic proximity Read ↗

Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes.Semantic proximity Read ↗

Calcium binding to PICK1 is essential for the intracellular retention of AMPA receptors underlying long-term depression.Semantic proximity Read ↗

Lipid binding regulates synaptic targeting of PICK1, AMPA receptor trafficking, and synaptic plasticity.Semantic proximity Read ↗

Interaction between the glutamate transporter GLT1b and the synaptic PDZ domain protein PICK1.Semantic proximity Read ↗

PICK1 links KIBRA and AMPA receptors in coiled-coil-driven supramolecular complexesSemantic proximity Read ↗

The PDZ domain of PICK1 differentially accepts protein kinase C-alpha and GluR2 as interacting ligands.Semantic proximity Read ↗

Corequirement of PICK1 binding and PKC phosphorylation for stable surface expression of the metabotropic glutamate receptor mGluR7.Semantic proximity Read ↗

The binding affinities of proteins interacting with the PDZ domain of PICK1.Semantic proximity Read ↗

PICK1 expression in the Drosophila central nervous system primarily occurs in the neuroendocrine system.Semantic proximity Read ↗

Serine 77 in the PDZ domain of PICK1 is a protein kinase Cα phosphorylation site regulated by lipid membrane binding.Semantic proximity Read ↗

PICK1 mediates synaptic recruitment of AMPA receptors at neurexin-induced postsynaptic sites.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.